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KMID : 0360319950270020238
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 2 p.238 ~ p.246
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Serum Insulin-like Growth Factor Binding Proteins Profiles in Hepatocelllular Carcinoma
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Abstract
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Recent findings have indicated that insulin-like growth factors(IGF-I &-Ⅱ) and it's binding proteins(IGFBPs) may play a role in neoplasia. Hepatoma is a common malignancy in this country and the liver is probably the source of most circulating
IGFs and
IGFBP-3.
We have studied serum IGFBPs pattern in hepatoma(n=20) and liver cirrhosis(n=10) by using western ligand blot(WLB) and radioimmunoassay(RIA). Serum IGFBP-3 level was significantly decreased in hepatoma and liver cirrhosis. Mean serum IGFBP-3
level
was
2443(±1258)ng/ml in hepatoma, 1308(±381)ng/ml in liver cirrhosis, and 4706(±519)ng/ml in healthy subject. There was a discrepancy of IGFBP-3 levels, as determined by RIA and WLB. This discrepancy can be explained by IGFB-3 protease activity,
which
was found in serum from some hepatoma but not from liver cirrhosis. We also observed the decreased level of serum IGFBP-2 in both groups. Serum IGFBP-1 and -4 were decreased in only liver cirrhosis.
We speculate the alteration of IGFBPs pattern in hepatoma would be due to decreased hepatic synthesis of IGFBPs, especially IGFBP-3 and serum IGFBP-3 protease activity, and the role of serum IGFBPs should be further studied.
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KEYWORD
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